After watching, please complete our 2-minute survey at https://is.gd/scivideos. Visit our website at http://sci.washington.edu. Presented by Gregory T. Carter, MD, MS, Medical Director, St. Luke’s Rehabilitation Institute, Spokane, Washington. Dr. Carter discusses the history of medical cannabis (marijuana) in the U.S., the physiological effects of cannabis on the central nervous system, and the current scientific evidence regarding the safety and effectiveness of cannabis as a treatment for neuropathic pain when used under a physician’s supervision.